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KMID : 0363220110490040334
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Korean Journal of Dermatology
2011 Volume.49 No. 4 p.334 ~ p.338
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Kim Byung-Chul
Seung Na-Reu
Park Eun-Ju
Kwon In-Ho
Kim Kwang-Ho
Kim Kwang-Joong
Park Hye-Rim
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Abstract
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Background: The astrocyte elevated gene-1 (AEG-1) was cloned as a novel HIV-1 and tumor necrosis factor-α- induced transcript from primary human fetal astrocytes. It has been reported that the AEG-1 expression is elevated in subsets of breast cancer, glioblastoma multiforme and melanoma cells, and AEG-1 cooperates with Ha-ras to promote the transformation of immortalized melanocytes. AEG-1 is thought to play a role in promoting cancer development and/or its maintenance.
Objective: The aim of this study is to determine whether AEG-1 is related to the pathogenesis of melanoma and other melanocytic lesions.
Methods: The nine biopsy specimens each of melanoma, dysplastic nevus, Spitz nevus and compound nevus were studied using immunohistochemical staining. The expressions of AEG-1 were evaluated using an immunostainingintensity- distribution index.
Results: The expression of AEG-1 was significantly higher in the melanoma and dysplastic nevus than in the compound nevus. The expression was also significantly higher in the melanoma than in the Spitz nevus.
Conclusion: AEG-1 may be related to the pathogenesis of both dysplastic nevus and melanoma, but it may not be related to Spitz nevus.
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KEYWORD
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Astrocyte elevated gene-1, Dysplastic nevus, Malignant melanoma, Spitz nevus
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